Hypoxia and human placental development.
نویسنده
چکیده
منابع مشابه
Oxygen regulation of macrophage migration inhibitory factor in human placenta.
Macrophage migration inhibitory factor (MIF) is an important proinflammatory cytokine involved in regulation of macrophage function. In addition, MIF may also play a role in murine and human reproduction. Although both first trimester trophoblast and decidua express MIF, the regulation and functional significance of this cytokine during human placental development remains unclear. We assessed M...
متن کاملHigh-altitude hypoxia and preeclampsia.
The influence of hypoxia (lowered arterial blood and/or tissue PO2) on fetoplacental development and the role of hypoxia in preeclampsia are major research foci in perinatal biology. While animal and cell models are of utility, we do not know whether artificial hypoxic stimuli mimic the pathological conditions attributed to hypoxic stress in vivo; we cannot distinguish the effects of hypoxia fr...
متن کاملTrophoblast biology, responses to hypoxia and placental dysfunction in preeclampsia.
Preeclampsia is a hypertensive disorder unique to human pregnancy that can result in significant morbidity and mortality for mother and fetus. While the etiology of preeclampsia is unknown, the placenta in general and trophoblast in particular is a prerequisite for the disease. We overview normal development of the human placenta, describe the role of hypoxia and other insults in placental inju...
متن کاملBeyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy
In the first trimester the extravillous cytotrophoblast cells occlude the uterine spiral arterioles creating a low oxygen environment early in pregnancy, which is essential for pregnancy success. Paradoxically, shallow trophoblast invasion and defective vascular remodelling of the uterine spiral arteries in the first trimester may result in impaired placental perfusion and chronic placental isc...
متن کاملChronic Hypoxemia in Late Gestation Decreases Cardiomyocyte Number but Does Not Change Expression of Hypoxia‐Responsive Genes
BACKGROUND Placental insufficiency is the leading cause of intrauterine growth restriction in the developed world and results in chronic hypoxemia in the fetus. Oxygen is essential for fetal heart development, but a hypoxemic environment in utero can permanently alter development of cardiomyocytes. The present study aimed to investigate the effect of placental restriction and chronic hypoxemia ...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 105 5 شماره
صفحات -
تاریخ انتشار 2000